Apolipoprotein-induced conversion of phosphatidylcholine bilayer vesicles into nanodisks

► Apolipophorin III spontaneously solubilizes phosphatidylcholine vesicles. ► ITC shows exothermic character of formation of DMPC nanodisks. ► Nanodisks are well protected from proteases. ► Cholesterol and sphingomyelin stimulate nanodisk formation. ► Nanodisk formation is efficient process for PC with acylchains of 14 C or shorter.