The importance of bacterial membrane composition in the structure and function of aurein 2.2 and selected variants

► The structure of aurein 2.2 and variants in different membranes is investigated. ► The membrane interactions of these peptides are also determined. ► The model membranes used are cardiolipin/PG and PE/PG. ► Results are compared to previous findings in PC/PG. ► Antimicrobial activity is correlated to the biophysical findings.