Insights into the biophysical properties of GABAA ion channels: Modulation of ion permeation by drugs and protein interactions

► Ion permeation through GABAA receptors is variable. ► Drugs and protein interactions modulate ion permeation through clustered channels. ► These data are reviewed and a model is presented. ► Permeation through the membrane pore is linked to intracellular protein interactions. ► Cellular signals that affect GABAA receptor interactions will affect neuronal function.