High water solubility and fold in amphipols of proteins with large hydrophobic regions: Oleosins and caleosin from seed lipid bodies

► Three integral proteins from lipid bodies efficiently solubilized in water. ► First structural results on lipid bodies proteins in solution with amphipols. ► Oleosins and caleosin contain more beta structures in amphipols than in SDS. ► Model for the secondary structure of the long hydrophobic domain of oleosins.