The lipid composition of a cell membrane modulates the interaction of an antiparasitic peptide at the air-water interface

► Antiparasitic peptides were incorporated in membrane models. ► Small amounts of peptide affect the monolayers of lipids. ► Surface pressure isotherms point to interactions between lipids and peptides. ► Interactions do not depend on the electrical charge. ► The lipid composition modulates the interaction with the lipophilic peptide.