Towards a structural understanding of the smallest known oncoprotein: Investigation of the bovine papillomavirus E5 protein using solution-state NMR

► This is the first application of solution-state NMR to study the E5 oncoprotein TM domain in detergent micelles. ► This study reveals monomer dimer equilibrium in SDS micelles. ► Structure of in vitro dimer is comparable to that of wild-type dimer found in vivo.