Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells

► Rapamycin inhibits epidermal growth factor-induced elevation of TRPM6 mRNA. ► Rapamycin decreases epidermal growth factor-induced Mg2+ influx. ► Rapamycin does not affect the human TRPM6 promoter activity. ► A PI3K/Akt/mTOR pathway is involved in the regulation of TRPM6 mRNA stability.