The Pseudomonas aeruginosa membranes: A target for a new amphiphilic aminoglycoside derivative?

► An amphiphilic neamine derivative active against sensitive and resistant bacteria. ►Neamine derivative interacts and destabilizes P. aeruginosa lipid membrane. ► Amphiphilic neamine derivative: from an intracellular to a membrane target activity. ►Small amphiphilic aminoglycosides targeting lipid membrane.