Specific inhibition of a pathogenic receptor tyrosine kinase by its transmembrane domain

►The TM domain of Neu/V664E specifically inhibits the phosphorylation of full-length Neu/V664E. ►The TM domain of wild-type Neu does not inhibit the phosphorylation of full-length Neu/V664E. ►Neu/V664E TM domain does not affect the phosphorylation of full-length FGFR3/A391E.