Curcumin is a lipid dependent inhibitor of the Na,K-ATPase that likely interacts at the protein-lipid interface

►Curcumin interacts with the Na,K-ATPase from within the membrane area. ►Curcumin potency is strongly modulated by the physical properties of the membrane. ►Recruitment of Na,K-ATPase into different membrane domains affects curcumin potency. ►Membrane lipids participate in the interaction of curcumin with the Na,K-ATPase.