The control of elongation by the yeast Ccr4-Not complex

► Ccr4-Not has many genetic and physical interactions with RNAPII elongation factors. ► Ccr4-Not associates with RNAPII in solution and within functional elongation complexes. ► Ccr4-Not promotes elongation through genes in vivo. ► Ccr4-Not directly activates arrested RNAPII. ► Not4 regulates co-transcriptional histone modifications through the destruction of Jhd2.