Nuclear organization and chromatin dynamics in yeast: Biophysical models or biologically driven interactions?

► 3D chromatin organization in nuclear space impacts nuclear functions. ► Biophysical models of chromatin accurately recapitulate observed nuclear organization. ► Saccharomyces cerevisiae is a simple model for studying nuclear organization. ► Numerous nuclear landmarks interact with defined chromatin elements. ► Chromatin is organized by global biophysical rules and local biological interactions.