New clues to understand the role of THO and other functionally related factors in mRNP biogenesis

► THO is a mRNP factor necessary for the formation of export-competent mRNAs. ► THO/TREX is recruited to all active RNAPII transcribed genes, accumulating towards the 3 ′end. ► THO and THSC/TREX-2 are two key mRNP with a role in the maintenance of genome integrity. ► THO is a dynamic factor transiently interacting with THSC/TREX-2, CIP29/Tho1 and related factors