Ubiquitin and assembly of export competent mRNP

► Histone H2B ubiquitylation affects late mRNA export events. ► Ubiquitin regulates co-transcriptional recruitment of export factors. ► THO is a platform coordinating mRNP assembly, 3′ end formation and release from transcription sites. ► mRNP surveillance at the pore is linked to an ultimate remodeling step before exit into the cytoplasm. ► Ubiquitylation may regulate multiple aspects of nuclear pore complex structure and function.