کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10799956 1054607 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells
چکیده انگلیسی
A series of dihydroindolizino indole derivatives were synthesized and their antitumor activity, ability to selectively interact and stabilize G-quadruplex DNA were studied. Results indicate that 4-cyanophenyl linked derivative (DHII-4CPh) is superior in all aspects. It is closely followed by thiophen-2-yl (DHII-TPh) and 3-methyl-1-phenyl-1H-pyrazol-4-yl (DHII-MPhPy) linked derivatives.219
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - General Subjects - Volume 1850, Issue 1, January 2015, Pages 129-140
نویسندگان
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