Glutathione transferases, regulators of cellular metabolism and physiology

► Glutathione transferases are known for their capacity to conjugate xenobiotics. ► Glutathione transferases isomerize intermediates in steroid hormone synthesis. ► Zeta class glutathione transferases catalyze a required step in tyrosine catabolism. ► Several glutathione transferases regulate signaling pathways through JNK. ► Some members of the GST family form and modulate ion channels.