The in vivo role of nuclear receptor corepressors in thyroid hormone action

► Mouse models allow assessment of the role of CoRs in NR signaling. ► CoRs mediate repression of positive targets by TR in the absence of T3. ► CoRs play a role in establishing a set point of HPT axis. ► CoRs attenuate transcriptional activity of NRs in the presence of ligands. ► CoR might be new drug targets for endocrine and metabolic disorders.