The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation

► Deiodinases contribute to the control of TH availability in different cell types. ► Deiodinase actions are part of the TH-mediated control of differentiation. ► Deiodinases are critical in cochlear and retinal maturation in pre/post-natal life. ► In muscle cells, deiodinases are required for myogenesis and muscle regeneration.