Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling

► Presentation of deiodinase-dependent thyroid hormone action ► Discussion of how D2 mediates T3 signaling and its regulation ► Physiological contribution of D2 to critical processes, such as control of basal metabolic rate ► New insights on D2's role in regulating the TSH-feedback mechanism