Effects of estradiol on the endocytic transport of vitamin D carrier protein in hepatocytes

► We examine the effects of estradiol on endocytosis of vitamin D-binding protein. ► Stimulation of such transport by estradiol (E2) occurs in female murine hepatocytes. ► Fulvestrant, an estrogen receptor antagonist, only partly inhibits this stimulation. ► Study helps delineate possible endocrine control mechanisms involving endocytosis.