Bacterial membrane disrupting dodecapeptide SC4 improves survival of mice challenged with Pseudomonas aeruginosa

► Dodecapeptide SC4 is highly effective against Pseudomonas aeruginosa (P.a.). ► SC4 attenuates inflammatory cytokine levels in serum. ► Combination treatment of SC4 and Zosyn is most effective at killing P.a. in vivo.