On the role of Wnt/β-catenin signaling in stem cells

► Wnt proteins are secreted glycoproteins that can activate different intracellular signaling pathways. ► Wnt signaling supports self-renewal and pluripotency of embryonic stem cells. ► Wnt signaling can improve reprogramming of somatic cells towards iPS. ► Wnt signaling is important for maintenance of intestinal stem cells.