Stem cell regulation by the Hippo pathway

► Recent data linking the Hippo pathway to stem cell renewal and differentiation is discussed. ► The Hippo pathway effectors TAZ and YAP control embryonic and induced pluripotent stem cell renewal. ► TAZ and YAP activity dictates mesenchymal stem cell differentiation. ► TAZ and YAP promote epithelial and neuronal progenitor proliferation. ► TAZ enhances cancer stem cell-like properties.