Chemotherapeutic agents enhance cell migration and epithelial-to-mesenchymal transition through transient up-regulation of tNOX (ENOX2) protein

► Doxorubicin treatment transiently up-regulates tNOX expression in human lung carcinoma A549 cells. ► Tamoxifen treatment also transiently up-regulates tNOX expression in A549 cells. ► The up-regulation of tNOX expression results in enhanced cell migration. ► Tamoxifen-induced cell migration is correlated with epithelial-to-mesenchymal transition.