The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation

► Transport of soy-derived peptides across intestinal epithelial cells was examined. ► The tripeptide VPY was identified as a novel substrate for the transporter PepT1. ► VPY reduced production of inflammatory cytokines in IECs and immune cells. ► VPY reduced the severity of DSS-induced colitis in mice. ► VPY may be a promising new therapeutic for the treatment of intestinal inflammation.