Evaluation of sialic acid-analogs for the attenuation of amyloid-beta toxicity

► Successful decoration of chitosan by different sialic acid analogs. ► Results show change in intrinsic toxicity before and after complexation of sugars. ► Demonstrated how unique structures effect Aβ toxicity attenuation. ► Results show importance of oxygen substitution and multi-OH tail of sialic acid. ► Results indicate oxygen containing structures will show therapeutic effectiveness.