Understanding the drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 due to R155K, A156V, D168A/E mutations: A computational study

► Drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 was explored. ► For the mutations at 155 and 168, the main reason is the destroy of key salt bridges. ► For A156V mutation, the origin of drug resistance is the change of binding pocket.