Type III and V collagens modulate the expression and assembly of EDA+ fibronectin in the extracellular matrix of defective Ehlers-Danlos syndrome fibroblasts

► Ehlers-Danlos syndrome cells lack collagens and fibronectin extracellular matrix. ► Collagens III and V restore the matrix containing the EDA+ fibronectin isotype. ► Collagens III and V induce fibronectin gene expression and maturation of EDA+ mRNA. ► Collagens induce recruitment of α5β1 and α9β1 integrin and FAK-mediated signal transduction.