Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract

► We show that CEppt is an effective inhibiter for α-synuclein aggregation. ► CEppt has a differential effect on the formation of soluble and insoluble aggregates. ► High molecular ratio of CEppt stabilizes oligomers. ► Drosophila model shows reduced brain aggregates and defective phenotype correction.