Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice

► MicroRNAs are modulated by polyphenols. ► Mice with diet-induced fatty liver disease were used to test interactions. ► Polyphenols accumulated in the liver and attenuated deleterious effects. ► Polyphenols induced changes in miR-103/107 and miR-122 expression. ► Regulation of liver fatty acid utilization is a probable common mechanism of action.