Liver X receptor and peroxisome proliferator-activated receptor agonist from Cornus alternifolia

►The metabolites isolated show potential active agonists for PPAR and LXR receptors. ►Four new natural products 1-4 were isolated from the leaves of Cornus alternifolia. ►Metabolite 1 is the first iridoid glycoside containing a β-glucopyranoside at C-6. ►Metabolite 5 showed potent agonistic activities for PPARα, PPARγ and LXR. ►The results presented can be used for further synthetic and pharmacological studies.