Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells

► Mitochondrial dysfunction-generated ROS promotes gastric cancer cell migration. ► Mitochondrial dysfunction-generated ROS increases β5-integrin protein expression. ► β5-integrin upregulation is required for the enhanced migration. ► Migratory cells exhibit mitochondrial dysfunction and high β5-integrin expression. ► Gastric cancers with higher β5-integrin expression show more aggressive behavior.