A T/C polymorphism in the GPX4 3′UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells

► Clones over-expressed a GPX4 3′UTR transgene with either T or C variant of rs713041. ► T/C polymorphism modulated effect of over-expression on selenoprotein hierarchy. ► T/C polymorphism modulated effect of transgene on sensitivity to oxidative challenge.