کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10801872 | 1055646 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
How actin/myosin crosstalks guide the adhesion, locomotion and polarization of cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: How actin/myosin crosstalks guide the adhesion, locomotion and polarization of cells How actin/myosin crosstalks guide the adhesion, locomotion and polarization of cells](/preview/png/10801872.png)
چکیده انگلیسی
Directed cell locomotion is driven by cyclic progression of the front and retraction of the end regulated by actin microtubule (MT) crosstalk. Adhesion domains (ADs) formed about integrin clusters act as biochemical steering and force generating centers. Their function is controlled in a Ca++- and force-dependent way by quaternary complexes of actin, IQGAP, calmodulin, and microtubule. The rhythmic cell progression is determined by the dynamic antagonism between the GTPases Rac-1 and Rho-A. The retraction is mediated by protease (P)-activated by Ca++ release from ER stores which mediates the dismantling and retraction of rearmost ADs by activation of RhoA and inhibition of Rac-1 in the cell-tissue adhesion zone.151
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1853, Issue 11, Part B, November 2015, Pages 3132-3142
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1853, Issue 11, Part B, November 2015, Pages 3132-3142
نویسندگان
Erich Sackmann,