کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10802189 | 1055666 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diverse roles of the ubiquitin system in NF-κB activation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
NF-κB is a transcription factor known to be involved in pleomorphic biological phenomena such as inflammation and immune responses. Abnormal activation of NF-κB has been reported in many pathological conditions, including allergic and auto-inflammatory diseases and malignancies. Therefore, the NF-κB activation pathway has been extensively studied and involvement of the ubiquitin conjugation system in the NF-κB activation pathways has been shown. Also non-degradable roles of the ubiquitin system have been revealed, recently. Several types of polyubiquitin chains exist and the type of chain seems to determine how ubiquitinated proteins are regulated. Roles of non-degradable types of polyubiquitin chains such as K63, linear and K11 chains in NF-κB activation is one of the big issues in NF-κB research. Thus, this short article discusses the differential roles of those polyubiquitin chains in NF-κB activation. This article is part of a Special Issue entitled: Ubiquitin-Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1843, Issue 1, January 2014, Pages 129-136
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1843, Issue 1, January 2014, Pages 129-136
نویسندگان
Kazuhiro Iwai,