Calcium, cancer and killing: The role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells

► Cytotoxic T lymphocyte (CTL) and natural killer (NK) cells kill cancer cells. ► Calcium modulates killing of cancer cells by CTL and NK cells. ► Several steps of the actual killing process are calcium dependent. ► A model is discussed how calcium influences the cancer-immune interaction.