RAGE in tissue homeostasis, repair and regeneration

► RAGE is a multiligand receptor involved in inflammation, diabetes, atherosclerosis, neurodegeneration and cancer. ► RAGE transduces effects of AGEs, HMGB1, β-amyloid fibrils, certain S100 proteins, and DNA and RNA in several cell types. ► Adaptor proteins associate with RAGE's cytoplasmic domain resulting in signaling. ► However, RAGE is also involved in tissue homeostasis and regeneration upon acute injury, and in resolution of inflammation.