Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin

► Rad6B/β-catenin physical interactions and mapping of the interacting regions ► Identification of the lysine 394 in β-catenin that is ubiquitinated by Rad6B ► Functional involvement of K394 of β-catenin in its transcriptional activity ► In vivo relation between Rad6 expression/activity, and Ub-β-cat in breast cancer