The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline

► PUF-8 and LIP-1 normally repress dedifferentiation by inhibiting MPK-1/ERK MAPK signaling. ► Active MPK-1/ERK controls initiation of dedifferentiation. ► RSKN-1/P90RSK, a downstream effector of MPK-1/ERK, is critical for dedifferentiation.