Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells

► Claudin-2 is expressed in human lung adenocarcinoma. ► Secreted epidermal growth factor increases claudin-2 expression. ► Claudin-2 expression is regulated by an EGFR/MEK/ERK/c-Fos pathway. ► Transcriptional activity of claudin-2 is inhibited by c-Fos siRNA. ► c-Fos binds to promoter region of claudin-2.