Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-κB activation in macrophages

► LPS-stimulated NF-κB activation and inflammatory cytokine production were further increased when SR-A ligand was present. ► Presence of SR-A ligand further enhanced LPS-promoted the association of SR-A with TLR4. ► Deficiency of either SR-A or TLR4 reduced the responses of macrophages to LPS challenge. ► Presence of SR-A is necessary for the amplification of LPS-induced response in macrophages.