Oestradiol signalling through the Akt-mTORC1-S6K1

► Oestradiol potentiated axonal and dendritic growth. ► Oestradiol antagonist (ICI) prevented axonal growth. ► Oestradiol antagonist (ICI) inhibited S6K activity as reported by pS6. ► Overexpression of Rheb or S6K on ICI-treated neurons restores pS6 and axonal growth.