RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway

► RNA helicase Ddx5 physically interacts with the RBP-J/NICD complex. ► RNA helicase Ddx5 is found at Notch target genes in vivo. ► RNA helicase Ddx5 acts as a co-activator in Notch signaling. ► The long non-coding RNA SRA associates with Ddx5 and NICD in T-cells and is a positive regulator of Notch signaling. ► Occupancy of p300 and histone acetylation is lost upon SRA knockdown and overexpression at Notch target genes.