PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B

► PTPA activated PP2A by decreasing P-PP2AC level with reduced tau phosphorylation. ► PTPA modulates the phosphorylation of PP2AC by PTP1B. ► PTPA level decreases in the brains of AD patients and transgenic mice models.