Post-translational modifications of Hsp90 and their contributions to chaperone regulation

► Heat shock protein 90 (Hsp90) is evolutionarily conserved. ► Hsp90 activates and maintains numerous signaling networks in normal and cancer cells. ► Hsp90 chaperone function is regulated by post-translational modifications of Hsp90 and various co-chaperones. ► Hsp90 post-translational modifications include phosphorylation, acetylation, S-nitrosylation, oxidation, and ubiquitination.