Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

► We summarize the current status of Hsp90 inhibitors based on their chemical classification. ► We present the current stage of clinical development for Hsp90 inhibitors in cancers. ► We discuss the assays and biomarkers currently implemented in clinic for Hsp90 inhibitors. ► We present strategies aimed at enhancing the clinical effectiveness of Hsp90 inhibitors in cancer.