The R2TP complex: Discovery and functions

► The R2TP (Rvb1-Rvb2-Tah1-Pih1) complex was identified in 2005 as an Hsp90 associated complex. ► The R2TP complex is conserved from yeast to higher eukaryotes. ► The complex is involved in box C/D snoRNP biogenesis. ► The complex is required for phosphatidylinositol-3 kinase-related protein kinase (PIKK) signalling. ► R2TP is involved in RNA polymerase II assembly.