Structure and function of the membrane deformation AAA ATPase Vps4

► Vps4 is a type-I AAA ATPases that functions with ESCRT-III in the deformation and fission of membranes. ► Vps4-mediated membrane fission plays an important role for MVB vesicle formation, cytokinesis and viral budding. ► Vps4 posses a dynamic quaternary structure that is regulated by the bound nucleotide and co-factors.