Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity

► Phagocyte NADPH oxidase (phox) is crucial to microbicidal activity of neutrophils. ► Modulation by peroxiredoxin 6 (Prdx6) presents a novel paradigm for phox. ► Prdx6 moves to plasma membrane and enhances activity in neutrophils and K562 line. ► Prdx6 retains phox complex in phox competent K562 cells. ► Prdx6 is critical for optimal phox activity.