Nicotinic stimulation induces Tristetraprolin over-production and attenuates inflammation in muscle

► Cholinergic stimulation induces anti-inflammatory response in skeletal muscle cells. ► Tristetraprolin is an essential player in the cholinergic anti-inflammatory pathway in muscles. ► Cholinergic signaling regulates the expression of mRNA processing factors and their apoptosis-related targets. ► Cholinergic imbalances in the neuromuscular junction alter polyA site selection in the anti-apoptotic Mcl-1 gene. ► Together, cholinergic signaling in muscle cells regulates inflammatory and apoptosis-related transcripts.